Severe Feline Infectious Peritonitis - Administer 2 Injections Daily

For severe cases of feline infectious peritonitis (FIP), we recommend administering two injections per day. Each injection should be 50% of the full daily dosage, spaced 12 hours apart.

 

 

 

Understanding GS-441524's Half-Life

 

Before diving into the benefits, it’s crucial to understand the half-life of GS-441524. This antiviral has a half-life of approximately 3 to 4 hours in the bloodstream, meaning its concentration is reduced by half every 4 hours. To illustrate,

 


let's examine a hypothetical scenario.

 

Consider a 4kg cat, 3.5 years old, diagnosed with Dry FIP, with no other complications. The daily recommended dosage using a 20mg/ml concentration would be 1.88ml. Here's how GS-441524 degrades in the body over 24 hours:

  • At injection: 1.88ml x 20mg/ml = 37.6mg of GS-441524

  • After 4 hours: 18.8mg remains

  • After 8 hours: 9.4mg remains

  • After 12 hours: 4.7mg remains

  • After 16 hours: 2.35mg remains

  • After 20 hours: 1.17mg remains

  • After 24 hours: 0.58mg remains

At the end of 24 hours, only 0.58mg of GS-441524 is left to combat FIP virus replication.

The Advantage of Two Injections Daily

Administering two injections per day, each at 50% of the daily dosage, maintains higher and more stable levels of GS-441524 in the bloodstream:

 

  • At injection: 1.88ml x 20mg/ml x 50% = 18.8mg of GS-441524

  • After 4 hours: 9.4mg remains

  • After 8 hours: 4.7mg remains

  • After 12 hours: 2.35mg remains

  • After 16 hours: 18.8mg from the second injection + 1.17mg from the first

  • After 20 hours: 9.4mg remains from the second injection + 0.58mg from the first

  • After 24 hours: 4.7mg remains from the second injection + 0.29mg from the first

 

 

Key Benefits

 

  • Higher GS-441524 Levels: Maintaining higher levels of GS-441524 ensures more effective viral suppression, crucial during the initial critical phase of treatment.

  • Reduced Injection Pain: For larger cats requiring higher dosages, splitting the daily dosage into two injections reduces the volume per injection, making it less painful. This is particularly beneficial given the acidic nature of GS-441524, which can cause discomfort during administration.


While administering one injection per day is perfectly acceptable, spacing out the dosage into two injections 12 hours apart can significantly enhance treatment efficacy and comfort.


 

Published by: FIPcureplus.com

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